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Zestril (Lisinopril) is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This lowers blood pressure and helps the heart to pump blood more easily.

Uses Lisinopril (lye-SIN-oh-pril) is used to treat high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. It may also be used for other conditions as determined by your doctor. How to take Take Lisinopril by mouth with or without food. Side effects All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome: cough, diarrhea, dizziness, headache, tiredness. Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; hoarseness); chest pain, dark urine, decreased urination; difficulty swallowing; infection (eg, fever, chills, persistent sore throat); irregular or slow heartbeat; stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. Symptoms of overdose may include fainting, severe dizziness or lightheadedness; weakness. If you suspect an overdose of Lisinopril, seek medical attention immediately. Precaution Do NOT use Lisinopril if: you are allergic to any ingredient in this medicine; you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor; you are in your second or third trimester of pregnancy Contact your doctor or health care provider right away if any of these apply to you. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances; if you are a woman of childbearing age;; if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney problems, or diabetes if you have a history of stroke, recent heart attack, or kidney transplant; if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma); if you are dehydrated or have low blood volume; if you have high blood potassium levels, low blood sodium levels, or are on a low salt (sodium) diet; if you are on dialysis or are scheduled to have major surgery. Lisinopril may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Lisinopril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Lisinopril may cause a serious side effect called angioedema. Lisinopril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse. Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur. Rarely, Lisinopril may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Check with your doctor before you use a salt substitute or a product that has potassium in it. Tell your doctor or dentist that you take Lisinopril before you receive any medical or dental care, emergency care, or surgery. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal. Tell your doctor if you develop any new symptoms. If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns. Diabetes patients- Lisinopril may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lab tests, including blood pressure, blood electrolyte levels, heart function, or kidney or liver function, may be performed while you use Lisinopril. These tests may be used to monitor your condition or check for side effects. Lisinopril may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Lisinopril is found in breast milk. Do not breast-feed while taking Lisinopril. Drug interactions Tell your health care provider if you are taking any other medicines, especially any of the following: Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased; Aldosterone blockers (eg, eplerenone), potassium-sparing diuretics (eg, spironolactone, triamterene), or potassium supplements because the risk of high blood potassium levels may be increased; Insulin, sulfonylureas (eg, glipizide), or other oral diabetes medicines (eg, metformin) because the risk of low blood sugar may be increased; Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur; Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) because they may decrease Lisinopril 's effectiveness; Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Lisinopril. This may not be a complete list of all interactions that may occur. Ask your health care provider if Lisinopril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Missed dose If you miss a dose of Lisinopril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once. Storage Store Lisinopril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lisinopril out of the reach of children and away from pets.

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