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Casodex (Bicalutamide) is a hormone therapy. Often given in combination with "LHRH agonist," another type of hormone therapy. It is a nonsteroidal anti-androgen, which blocks the stimulatory action of androgens (male hormones), e.g. dihydrotestosterone, on prostate cancer.

Uses Bicalutamide (bye ka LOO ta mide) therapy is for men with advanced prostate cancer at stage D2, when there is evidence of metastases (cancer spread) to other areas of the body. How to take Bicalutamide is a pill, taken by mouth with a full glass of water. It is taken once a day and is usually started at the same time LHRH therapy is started. It should be taken at the same time each day, with or without food. You should empty your bladder (urinate) before taking the medication. In some cases (e.g. spinal cord metastasis), Bicalutamide will be started approximately 5-7 days before you receive the LHRH agonist. Take Bicalutamide exactly as directed by your doctor. Side effects Stop taking Bicalutamide and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives). Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: chest pain, difficulty breathing, urinary retention or inability to urinate (for 8-12 hours). Contact your health care provider within 24 hours of noticing any of the following: Nausea (interferes with ability to eat and unrelieved with prescribed medication); Vomiting (vomiting more than 4-5 times in a 24 hour period); Diarrhea (4-6 episodes in a 24-hour period). Other less serious side effects may be more likely to occur. Continue to take Bicalutamide and talk to your doctor if you experience: hot flashes, decreased sex drive or impotence, headache, nausea or vomiting, diarrhea or constipation, breast tenderness or swelling, weakness, or pain in the back or pelvic areas. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Precaution Before taking Bicalutamide, tell your doctor if you are allergic to it; or if you have any other allergies. Before using this medication, tell your doctor your medical history, especially of: liver disease. Tell your doctor of all nonprescription or prescription medication you use, particularly of: blood thinners. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. To minimize these effects and flushing of the face, limit alcoholic beverages. Diabetic patients should carefully monitor their serum glucose. Do not start or stop any medicine without doctor approval. Drug interactions Before using this medication, tell your doctor of all prescription and nonprescription products you may use. Bicalutamide is known to interact with the following drugs: Quadramet, Arava, Avonex, Avonex Prefilled Syringe, Betaseron, Cisapride, Clofarabine, Clolar, Echinacea, Folex PFS, Leflunomide, Methotrexate, Naltrexone, Propulsid, Rebif, ReVia, Rheumatrex Dose Pack, Terfenadine, Thioguanine, Trexall, Vivitrol, Tnisindione, Coumadin, Dicumarol, Jantoven, Miradon, Warfarin. Missed dose Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication unless your doctor directs otherwise. Storage Store at room temperature between 68 and 77 degrees F (20 to 25 degrees C) away from heat and light. Do not store in the bathroom. Keep this and all medications out of the reach of children.

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